Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection

Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection

Diabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregu...

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Main Authors: Guzel Bikbova, Toshiyuki Oshitari, Takayuki Baba, Shuichi Yamamoto
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2016/5140823
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spelling doaj-3e9edfdd3d2b4a97bc55f04dd711a0fe2020-11-25T00:30:05ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/51408235140823Neuronal Changes in the Diabetic Cornea: Perspectives for NeuroprotectionGuzel Bikbova0Toshiyuki Oshitari1Takayuki Baba2Shuichi Yamamoto3Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670, JapanDiabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregularity. This review presents recent findings on impaired corneal innervation in diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy. Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic keratopathy are presented.http://dx.doi.org/10.1155/2016/5140823
collection DOAJ
language English
format Article
sources DOAJ
author Guzel Bikbova
Toshiyuki Oshitari
Takayuki Baba
Shuichi Yamamoto
spellingShingle Guzel Bikbova
Toshiyuki Oshitari
Takayuki Baba
Shuichi Yamamoto
Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection
BioMed Research International
author_facet Guzel Bikbova
Toshiyuki Oshitari
Takayuki Baba
Shuichi Yamamoto
author_sort Guzel Bikbova
title Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection
title_short Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection
title_full Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection
title_fullStr Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection
title_full_unstemmed Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection
title_sort neuronal changes in the diabetic cornea: perspectives for neuroprotection
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2016-01-01
description Diabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregularity. This review presents recent findings on impaired corneal innervation in diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy. Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic keratopathy are presented.
url http://dx.doi.org/10.1155/2016/5140823
work_keys_str_mv AT guzelbikbova neuronalchangesinthediabeticcorneaperspectivesforneuroprotection
AT toshiyukioshitari neuronalchangesinthediabeticcorneaperspectivesforneuroprotection
AT takayukibaba neuronalchangesinthediabeticcorneaperspectivesforneuroprotection
AT shuichiyamamoto neuronalchangesinthediabeticcorneaperspectivesforneuroprotection
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