Monitoring Patient Response to Pembrolizumab With Peripheral Blood Exhaustion Marker Profiles

Monitoring Patient Response to Pembrolizumab With Peripheral Blood Exhaustion Marker Profiles

Exhausted T cells are effector T cells that are silenced due to continuous T cell receptor (TCR) stimulation from persistent antigens. Characteristics of exhaustion include the increased expression of multiple inhibitory receptors such as programme death-1[PD-1], lymphocyte activation gene 3 [LAG-3]...

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Bibliographic Details
Main Authors: Moira Graves, Giovana CelliMarchett, Belinda van Zyl, Denise Tang, Ricardo E. Vilain, Andre van der Westhuizen, Nikola A. Bowden
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Medicine
Subjects:
melanoma
pembrolizumab
T cell exhaustion
PD-1
TIM-3
LAG-3
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00113/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00113/full

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