Characterization of antibodies in single-chain format against the E7 oncoprotein of the Human papillomavirus type 16 and their improvement by mutagenesis

Characterization of antibodies in single-chain format against the E7 oncoprotein of the Human papillomavirus type 16 and their improvement by mutagenesis

<p>Abstract</p> <p>Background</p> <p>Human papillomaviruses (HPV) are the etiological agents of cervical cancer. The viral E7 protein plays a crucial role in viral oncogenesis. Many strategies have been explored to block the E7 oncoprotein activity. The single-chain var...

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Bibliographic Details
Main Authors: Accardi Luisa, Giorgi Colomba, Donà Maria
Format: Article
Language:English
Published: BMC 2007-01-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/7/25

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