SGLT2 inhibitors and lower limb complications: the diuretic-induced hypovolemia hypothesis

SGLT2 inhibitors and lower limb complications: the diuretic-induced hypovolemia hypothesis

Abstract In a recent meta-analysis of randomized controlled trials of sodium glucose co-transporter 2 inhibitors (SGLT2i) in patients with diabetes, Lin and colleagues showed a positive association between SGLT2i-induced blood pressure and weight reduction and the risk of lower limb events. These re...

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Bibliographic Details
Main Authors: Louis Potier, Kamel Mohammedi, Gilberto Velho, Ronan Roussel
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cardiovascular Diabetology
Subjects:
SGLT2 inhibitors
lower limb events
amputations
diuretics
hypovolemia
Online Access:https://doi.org/10.1186/s12933-021-01301-x

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