Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor

Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor

Influenza A viruses leading to infectious respiratory diseases cause seasonal epidemics and sometimes periodic global pandemics. Viral polymerase is an attractive target in inhibiting viral replication, and 4′-ethynyladenosine, which has been reported as a highly potent anti-human immunode...

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Bibliographic Details
Main Authors: Toshifumi Takeuchi, Nongluk Sriwilaijaroen, Ayako Sakuraba, Ei Hayashi, Shinji Kamisuki, Yasuo Suzuki, Hiroshi Ohrui, Fumio Sugawara
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
4′-ethynyl-2′-deoxyadenosine 5′-monophosphate
influenza
anti-influenza activity
Online Access:https://www.mdpi.com/1420-3049/24/14/2603

Internet

https://www.mdpi.com/1420-3049/24/14/2603

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