Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

Cognitive impairment in Alzheimer's disease (AD) is strongly associated with both extensive deposition of amyloid β peptides and oxidative stress, but the exact role of these indices in the development of dementia is not clear. This study was designed to determine the relationship between cogni...

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Bibliographic Details
Main Authors: Annadora J. Bruce-Keller, Sunita Gupta, Alecia G. Knight, Tina L. Beckett, Jessica M. McMullen, Paulina R. Davis, M. Paul Murphy, Linda J. Van Eldik, Daret St Clair, Jeffrey N. Keller
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Neurobiology of Disease
Subjects:
Aging
Dementia
Oxidative stress
Redox signaling pathways
Synapse loss
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002385

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