Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]

B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1...

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Main Authors: Juan Carlos Yam-Puc, Lingling Zhang, Yang Zhang, Kai-Michael Toellner
Format: Article
Language:English
Published: F1000 Research Ltd 2018-04-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-429/v1
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spelling doaj-3e5e95e9b1414aa891752f528caac4172020-11-25T03:48:42ZengF1000 Research LtdF1000Research2046-14022018-04-01710.12688/f1000research.13567.114737Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]Juan Carlos Yam-Puc0Lingling Zhang1Yang Zhang2Kai-Michael Toellner3Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKB-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.https://f1000research.com/articles/7-429/v1
collection DOAJ
language English
format Article
sources DOAJ
author Juan Carlos Yam-Puc
Lingling Zhang
Yang Zhang
Kai-Michael Toellner
spellingShingle Juan Carlos Yam-Puc
Lingling Zhang
Yang Zhang
Kai-Michael Toellner
Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
F1000Research
author_facet Juan Carlos Yam-Puc
Lingling Zhang
Yang Zhang
Kai-Michael Toellner
author_sort Juan Carlos Yam-Puc
title Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
title_short Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
title_full Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
title_fullStr Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
title_full_unstemmed Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
title_sort role of b-cell receptors for b-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2018-04-01
description B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.
url https://f1000research.com/articles/7-429/v1
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AT linglingzhang roleofbcellreceptorsforbcelldevelopmentandantigeninduceddifferentiationversion1referees2approved
AT yangzhang roleofbcellreceptorsforbcelldevelopmentandantigeninduceddifferentiationversion1referees2approved
AT kaimichaeltoellner roleofbcellreceptorsforbcelldevelopmentandantigeninduceddifferentiationversion1referees2approved
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