Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited

Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited

Miller Fisher Syndrome (MFS), a variant of Guillain Barre Syndrome (GBS), and amyotrophic lateral sclerosis (ALS) are two rare neuromuscular diseases that are usually unrelated. While ganglioside antibodies have a common relation with MFS and GBS, they have also been found in association, albeit les...

Full description

Bibliographic Details
Main Authors: Michael Repajic, Syed Husain, Azadeh Ghassemi, Manvel Kondradzhyan, Antonio Liu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Amyotrophic lateral sclerosis
Miller Fisher syndrome
Ganglioside antibodies
GQ1b
Online Access:http://www.sciencedirect.com/science/article/pii/S266635462100034X
id doaj-3e57e531ac334b66857db93f0f59d5f0
record_format Article
spelling doaj-3e57e531ac334b66857db93f0f59d5f02021-06-10T04:58:10ZengElsevierBrain, Behavior, & Immunity - Health2666-35462021-05-0113100231Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisitedMichael Repajic0Syed Husain1Azadeh Ghassemi2Manvel Kondradzhyan3Antonio Liu4Neurology, Adventist Health White Memorial, Los Angeles, CA, USANeurology, Adventist Health White Memorial, Los Angeles, CA, USAInternal Medicine, Connecticut Institute for Communities, Danbury, CT, USANeurology, Adventist Health White Memorial, Los Angeles, CA, USANeurology, Adventist Health White Memorial, Los Angeles, CA, USA; Corresponding author.Miller Fisher Syndrome (MFS), a variant of Guillain Barre Syndrome (GBS), and amyotrophic lateral sclerosis (ALS) are two rare neuromuscular diseases that are usually unrelated. While ganglioside antibodies have a common relation with MFS and GBS, they have also been found in association, albeit less commonly, with ALS. A patient experiencing MFS and then ALS in tandem has never been documented. We discuss a case demonstrating these findings, with GQ1b elevated on both occasions. The pathophysiologic role of GQ1b is explored.http://www.sciencedirect.com/science/article/pii/S266635462100034XAmyotrophic lateral sclerosisMiller Fisher syndromeGanglioside antibodiesGQ1b
collection DOAJ
language English
format Article
sources DOAJ
author Michael Repajic
Syed Husain
Azadeh Ghassemi
Manvel Kondradzhyan
Antonio Liu
spellingShingle Michael Repajic
Syed Husain
Azadeh Ghassemi
Manvel Kondradzhyan
Antonio Liu
Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited
Brain, Behavior, & Immunity - Health
Amyotrophic lateral sclerosis
Miller Fisher syndrome
Ganglioside antibodies
GQ1b
author_facet Michael Repajic
Syed Husain
Azadeh Ghassemi
Manvel Kondradzhyan
Antonio Liu
author_sort Michael Repajic
title Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited
title_short Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited
title_full Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited
title_fullStr Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited
title_full_unstemmed Amyotrophic lateral sclerosis in a patient who recovered from Miller Fisher Syndrome: The role of GQ1b antibody revisited
title_sort amyotrophic lateral sclerosis in a patient who recovered from miller fisher syndrome: the role of gq1b antibody revisited
publisher Elsevier
series Brain, Behavior, & Immunity - Health
issn 2666-3546
publishDate 2021-05-01
description Miller Fisher Syndrome (MFS), a variant of Guillain Barre Syndrome (GBS), and amyotrophic lateral sclerosis (ALS) are two rare neuromuscular diseases that are usually unrelated. While ganglioside antibodies have a common relation with MFS and GBS, they have also been found in association, albeit less commonly, with ALS. A patient experiencing MFS and then ALS in tandem has never been documented. We discuss a case demonstrating these findings, with GQ1b elevated on both occasions. The pathophysiologic role of GQ1b is explored.
topic Amyotrophic lateral sclerosis
Miller Fisher syndrome
Ganglioside antibodies
GQ1b
url http://www.sciencedirect.com/science/article/pii/S266635462100034X
work_keys_str_mv AT michaelrepajic amyotrophiclateralsclerosisinapatientwhorecoveredfrommillerfishersyndrometheroleofgq1bantibodyrevisited
AT syedhusain amyotrophiclateralsclerosisinapatientwhorecoveredfrommillerfishersyndrometheroleofgq1bantibodyrevisited
AT azadehghassemi amyotrophiclateralsclerosisinapatientwhorecoveredfrommillerfishersyndrometheroleofgq1bantibodyrevisited
AT manvelkondradzhyan amyotrophiclateralsclerosisinapatientwhorecoveredfrommillerfishersyndrometheroleofgq1bantibodyrevisited
AT antonioliu amyotrophiclateralsclerosisinapatientwhorecoveredfrommillerfishersyndrometheroleofgq1bantibodyrevisited
_version_ 1721385558287056896

Similar Items