Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.

The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturat...

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Main Authors: Emerson H Yoshimura, Nadine W Santos, Erica Machado, Bruna C Agustinho, Lucelia M Pereira, Sílvia C de Aguiar, Anacharis B Sá-Nakanishi, Cecília E Mareze-da-Costa, Lucia M Zeoula
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5898750?pdf=render
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spelling doaj-3e53dacf9e834e809cf08d65662cf0f42020-11-25T00:43:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019583910.1371/journal.pone.0195839Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.Emerson H YoshimuraNadine W SantosErica MachadoBruna C AgustinhoLucelia M PereiraSílvia C de AguiarAnacharis B Sá-NakanishiCecília E Mareze-da-CostaLucia M ZeoulaThe increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced). Experimental treatments were: control (water), whole common milk (COM-M), milk enriched with PUFA (PUFA-M), milk enriched with PUFA and polyphenols (PUFA/P-M) through a special diet offered to dairy cows. Milk supplementation at a dose 5 mL/kg body weight was performed for 77 days, 42 days before and 35 days after diabetes induction. The COM-M supplementation increased brown fat deposits, reduced post-induction glucose levels, reduced blood fructosamine levels, and improved glucose tolerance. Milk enriched with PUFA reduced final fasting glucose, LDL levels, and improved blood antioxidant capacity. Milk enriched with PUFA and polyphenols promoted an increase in gastrocnemius muscle mass, and a reduction in mesenteric fat and LDL levels. Milk intake, with an emphasis on milk enriched with PUFA and polyphenols, attenuated the metabolic disorders of streptozotocin-induced diabetes in rats.http://europepmc.org/articles/PMC5898750?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Emerson H Yoshimura
Nadine W Santos
Erica Machado
Bruna C Agustinho
Lucelia M Pereira
Sílvia C de Aguiar
Anacharis B Sá-Nakanishi
Cecília E Mareze-da-Costa
Lucia M Zeoula
spellingShingle Emerson H Yoshimura
Nadine W Santos
Erica Machado
Bruna C Agustinho
Lucelia M Pereira
Sílvia C de Aguiar
Anacharis B Sá-Nakanishi
Cecília E Mareze-da-Costa
Lucia M Zeoula
Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.
PLoS ONE
author_facet Emerson H Yoshimura
Nadine W Santos
Erica Machado
Bruna C Agustinho
Lucelia M Pereira
Sílvia C de Aguiar
Anacharis B Sá-Nakanishi
Cecília E Mareze-da-Costa
Lucia M Zeoula
author_sort Emerson H Yoshimura
title Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.
title_short Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.
title_full Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.
title_fullStr Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.
title_full_unstemmed Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.
title_sort functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced). Experimental treatments were: control (water), whole common milk (COM-M), milk enriched with PUFA (PUFA-M), milk enriched with PUFA and polyphenols (PUFA/P-M) through a special diet offered to dairy cows. Milk supplementation at a dose 5 mL/kg body weight was performed for 77 days, 42 days before and 35 days after diabetes induction. The COM-M supplementation increased brown fat deposits, reduced post-induction glucose levels, reduced blood fructosamine levels, and improved glucose tolerance. Milk enriched with PUFA reduced final fasting glucose, LDL levels, and improved blood antioxidant capacity. Milk enriched with PUFA and polyphenols promoted an increase in gastrocnemius muscle mass, and a reduction in mesenteric fat and LDL levels. Milk intake, with an emphasis on milk enriched with PUFA and polyphenols, attenuated the metabolic disorders of streptozotocin-induced diabetes in rats.
url http://europepmc.org/articles/PMC5898750?pdf=render
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