The multiple mechanisms of MCL1 in the regulation of cell fate

The multiple mechanisms of MCL1 in the regulation of cell fate

In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis re...

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Main Authors: Hayley Widden, William J. Placzek
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02564-6
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spelling doaj-3e4c89c0ce7e405aa2ea6b1f132107cc2021-09-05T11:21:09ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111210.1038/s42003-021-02564-6The multiple mechanisms of MCL1 in the regulation of cell fateHayley Widden0William J. Placzek1Department of Biochemistry and Molecular Genetics, University of Alabama at BirminghamDepartment of Biochemistry and Molecular Genetics, University of Alabama at BirminghamIn this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis regulation. They discuss which pathways are likely to be impacted by emerging MCL1 inhibitors, as well as highlight non-cancerous disease states that could deploy BH3-mimetics in the future.https://doi.org/10.1038/s42003-021-02564-6
collection DOAJ
language English
format Article
sources DOAJ
author Hayley Widden
William J. Placzek
spellingShingle Hayley Widden
William J. Placzek
The multiple mechanisms of MCL1 in the regulation of cell fate
Communications Biology
author_facet Hayley Widden
William J. Placzek
author_sort Hayley Widden
title The multiple mechanisms of MCL1 in the regulation of cell fate
title_short The multiple mechanisms of MCL1 in the regulation of cell fate
title_full The multiple mechanisms of MCL1 in the regulation of cell fate
title_fullStr The multiple mechanisms of MCL1 in the regulation of cell fate
title_full_unstemmed The multiple mechanisms of MCL1 in the regulation of cell fate
title_sort multiple mechanisms of mcl1 in the regulation of cell fate
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis regulation. They discuss which pathways are likely to be impacted by emerging MCL1 inhibitors, as well as highlight non-cancerous disease states that could deploy BH3-mimetics in the future.
url https://doi.org/10.1038/s42003-021-02564-6
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