An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway

An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway

Objective: Angiogenesis plays a vital role in tumor growth and metastasis. Here, we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A (VEGFA ) at the transcriptional level to treat triple-negative breast cancer (TNBC). Methods: We used a cell-based...

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Bibliographic Details
Main Authors: Xiaotong Zhang, Gengyi Zou, Xiyang Li, Lun Wang, Tianyu Xie, Jin Zhao, Longlong Wang, Shunchang Jiao, Rong Xiang, Haoyu Ye, Yi Shi
Format: Article
Language:English
Published: China Anti-Cancer Association 2020-08-01
Series:Cancer Biology & Medicine
Subjects:
isoflavone
mta2
serrs
tumor angiogenesis
vegfa
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1675

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