Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits

Definitive evidence for functional remapping after stroke remains lacking. Here, the authors performed in vivo intrinsic signal imaging and two-photon calcium imaging of sensory-evoked responses before and after photothrombotic stroke and found no evidence of remapping of lost functionalities to new...

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Main Authors:	William A. Zeiger, Máté Marosi, Satvir Saggi, Natalie Noble, Isa Samad, Carlos Portera-Cailliau
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24211-8

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spelling	doaj-3e49f8fd802b4abc9f3b7efa048768d12021-06-27T11:13:11ZengNature Publishing GroupNature Communications2041-17232021-06-0112111410.1038/s41467-021-24211-8Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuitsWilliam A. Zeiger0Máté Marosi1Satvir Saggi2Natalie Noble3Isa Samad4Carlos Portera-Cailliau5Department of Neurology, David Geffen School of Medicine, University of California Los AngelesDepartment of Neurology, David Geffen School of Medicine, University of California Los AngelesDepartment of Neurology, David Geffen School of Medicine, University of California Los AngelesDepartment of Neurology, David Geffen School of Medicine, University of California Los AngelesDepartment of Neurology, David Geffen School of Medicine, University of California Los AngelesDepartment of Neurology, David Geffen School of Medicine, University of California Los AngelesDefinitive evidence for functional remapping after stroke remains lacking. Here, the authors performed in vivo intrinsic signal imaging and two-photon calcium imaging of sensory-evoked responses before and after photothrombotic stroke and found no evidence of remapping of lost functionalities to new circuits in peri-infarct cortex.https://doi.org/10.1038/s41467-021-24211-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	William A. Zeiger Máté Marosi Satvir Saggi Natalie Noble Isa Samad Carlos Portera-Cailliau
spellingShingle	William A. Zeiger Máté Marosi Satvir Saggi Natalie Noble Isa Samad Carlos Portera-Cailliau Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits Nature Communications
author_facet	William A. Zeiger Máté Marosi Satvir Saggi Natalie Noble Isa Samad Carlos Portera-Cailliau
author_sort	William A. Zeiger
title	Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits
title_short	Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits
title_full	Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits
title_fullStr	Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits
title_full_unstemmed	Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits
title_sort	barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Definitive evidence for functional remapping after stroke remains lacking. Here, the authors performed in vivo intrinsic signal imaging and two-photon calcium imaging of sensory-evoked responses before and after photothrombotic stroke and found no evidence of remapping of lost functionalities to new circuits in peri-infarct cortex.
url	https://doi.org/10.1038/s41467-021-24211-8
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Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits

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