α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on <i>Escherichia coli</i>. Two of them are among the best 1-deoxy-<span style="font-variant: small-caps;">d</span>-xylulose...

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Bibliographic Details
Main Authors: Aurore Dreneau, Fanny S. Krebs, Mathilde Munier, Chheng Ngov, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
α,α-difluorophosphonate
deoxyxylulose phosphate reductoisomerase
1-deoxy-<span style="font-variant: small-caps">d</span>xylulose 5-phosphate reductoisomerase (DXR)
antimicrobial
fosmidomycin
isoprenoid biosynthesis
Online Access:https://www.mdpi.com/1420-3049/26/16/5111

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https://www.mdpi.com/1420-3049/26/16/5111

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