The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer

The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer

The cell cycle involves a network of proteins that modulate the sequence and timing of proliferation events. Unregulated proliferation is the most fundamental hallmark of cancer; thus, changes in cell cycle control are at the heart of malignant transformation processes. Several cellular processes ca...

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Bibliographic Details
Main Authors: Marina Andrade-Tomaz, Izadora de Souza, Clarissa Ribeiro Reily Rocha, Luciana Rodrigues Gomes
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
autophagy
chaperone-mediated autophagy (CMA), cell cycle
cancer
checkpoints
MYC
hypoxia-inducible factor-1 subunit alpha (HIF-1α), checkpoint kinase 1 (CHK1)
Online Access:https://www.mdpi.com/2073-4409/9/9/2140

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