Methods of diagnosis in cervical neoplasia

• Main Authors: Mariana Bratu, Eduard Crauciuc, Ovidiu Toma, Dragos Crauciuc, Doina Iancu, Florentina Pricop
• Format: Article
• Language: English
• Published: "Alexandru Ioan Cuza" University of Iași 2010-06-01
• Series: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
• Online Access: http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/873

The early screening of a precancerous lesion that can develop spontaneously into a cancerous lesion thatis first non-invasive and then invasive. Materials and methods. The study group was made of 1485 patients who were hospitalized between 2001 and 2009 in the Section of Obstetrics and Gynecology of ?Sf. Apostol Andrei? Emergency Hospital in Gala?i. The patients filled in a questionnaire on a sheet of paper in a freely consented way and they were diagnosed with cervical cancer by a cytologic and colposcopic examination, biopsy and other complementary examinations. Results and discussions. It is obvious that, even if cervical carcinoma benefits now from a remarkable methodology of detecting the early forms and even the precursor lesions, in our country this lesion has an important frequency and even represents a public health issue with important social-economic implications; in most cases it affects people in full physical and procreative activity; it implies a laborious therapy, long time hospitalization and high costs. The risk of getting infected with HPV(human papilloma virus) is at least 50% for the sexually active people for the rest of their lives. Although most infections eliminate with the help of our own immunity, the people who are infected are not aware of HPV presence and they can spread the virus. When our own immune system cannot eliminate the infection, the persistence of the viral oncogenic strains from the cervical mucosa can lead to the appearance of precancerous lesions. The cytological examination is a simple and fast method that is also cheap and reliable being considered the most effective technique for preventing and detecting the precancerous conditions of the cervix, which, treated correctly, can offer a primary prevention of cervical cancer. The diagnostic certainty was accomplished exclusively by histopathology of the material obtained during biopsy. Conclusions. We consider that the patients with cervical cancer, no matter what their condition stage is when they come to see the doctor must never be abandoned because in many cases they have a satisfactory evolution after following a complex and well led treatment.