2.2 Modest Region-Specific, Sex-Independent Aortic Remodelling when Hypertension is Superimposed on Aging

Background: Aging and hypertension often co-occur, which complicates distinguishing their biomechanical effects on arteries clinically. While aortic elastin (half-life ~70 years) is reduced in human aging, in mouse aging (lifespan ~2 years) it remains mostly intact. Knock-out of elastin-associated g...

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Bibliographic Details
Main Authors: Bart Spronck, Jacopo Ferruzzi, Alexander W. Caulk, Sae-Il Murtada, Jay D. Humphrey
Format: Article
Language:English
Published: Atlantis Press 2020-02-01
Series:Artery Research
Online Access:https://www.atlantis-press.com/article/125934391/view