Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum.

Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum.

Fine tuning of the Wnt/β-catenin signaling pathway is essential for the proper development and function of the liver. Aberrant activation of this pathway is observed in 20%-40% of hepatocellular carcinomas (HCC). Notum encodes a secreted Wnt deacylase that inhibits Wnt activity and thereby restricts...

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Bibliographic Details
Main Authors: Frédéric Canal, Sara Charawi, Gisèle Grimber, Christophe Houbron, Valérie Drouet, Sabine Colnot, Benoit Terris, Catherine Cavard, Christine Perret
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4790944?pdf=render

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