P23 PREDICTION OF TOTAL AND CAUSE-SPECIFIC MORTALITY INCIDENCE AS WELL AS CARDIOVASCULAR MORBIDITY BY USE OF NON-INVASIVE MEASUREMENT OF CAROTID- FEMORAL PULSE WAVE VELOCITY AS A MEASURE OF ARTERIAL STIFFNESS

• Main Authors: Peter Nilsson, Mikael Gottsäter, Abd al-Hakim Fatehali
• Format: Article
• Language: English
• Published: Atlantis Press 2017-12-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930339/view

Objective: Arterial stiffness (AS) increases with age and predicts total mortality and total cardiovascular (CV) events. It has also been shown that positive family history (FH+) of cardiometabolic disease influences AS. We aimed to: 1) examine if AS predicts total mortality among elderly subjects, as well as total, fatal, and non-fatal CV events; and 2) to assess if FH+ influences the prediction of AS. Methods: Participants from the Malmö Diet Cancer CV cohort (MDC-CV; n = 3,056, mean age 71 years, 40% men) in Sweden were examined during 2007–2012. AS was measured with carotid-femoral pulse wave velocity (c-f PWV; Sphygmocor®). Follow-up started from date of measurement and ended at death, emigration or on 31st December 2014. Hazard ratios (HRs) with 95% confidence intervals were computed using multivariable Cox and competing risks regression (sub-hazard ratio, SHR) adjusting for age, sex, cardiovascular risk factors, prevalent cardiometabolic diseases and FH+. Results: c-f PWV (per log-unit) significantly predicted total mortality, HR 2.57 (95%CI: 1.28–5.16, p = 0.008), after full adjustment for risk factors, and HR 3.01 (95%CI: 1.41–6.42) after adding FH. The prediction of CV events was of borderline significance, HR 1.85 (95%CI: 0.91–3.78, p = 0.09). FH+ contribution to c-f PWV prediction of non-CV mortality was of borderline significance SHR 2.30 (95%CI: 0.89–5.95, p = 0.085). Conclusion: Arterial stiffness (c-f PWV) predicts total mortality, even adjusted for family history. Thus c-f PWV is a promising risk marker for total mortality, beyond the prediction offered by conventional risk factors.