Cinnamic Aldehyde Inhibits Lipopolysaccharide-Induced Chondrocyte Inflammation and Reduces Cartilage Degeneration by Blocking the Nuclear Factor-Kappa B Signaling Pathway

Cinnamic Aldehyde Inhibits Lipopolysaccharide-Induced Chondrocyte Inflammation and Reduces Cartilage Degeneration by Blocking the Nuclear Factor-Kappa B Signaling Pathway

Osteoarthritis (OA), as one of the top 10 causes of physical disability, is characterized by inflammation of the synovial membrane and progressive destruction of the articular cartilage. Cinnamic aldehyde (CA), an α,β-unsaturated aldehyde extracted from the traditional Chinese herbal medicine cinnam...

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Bibliographic Details
Main Authors: Pu Chen, Anmin Ruan, Jun Zhou, Liuwei Huang, Xiaozhe Zhang, Yufeng Ma, QingFu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
cinnamic aldehyde
knee osteoarthritis
chondrocyte inflammation
chondrocyte degeneration, NF-kB signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00949/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00949/full

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