LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.

Bibliographic Details
Main Authors: María Ángeles Marqués-Torrejón, Charles A. C. Williams, Benjamin Southgate, Neza Alfazema, Melanie P. Clements, Claudia Garcia-Diaz, Carla Blin, Nerea Arranz-Emparan, Jane Fraser, Noor Gammoh, Simona Parrinello, Steven M. Pollard
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22813-w
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spelling doaj-3e0ce24ca18642ab920706ba35de6dae2021-05-11T14:49:28ZengNature Publishing GroupNature Communications2041-17232021-05-0112111510.1038/s41467-021-22813-wLRIG1 is a gatekeeper to exit from quiescence in adult neural stem cellsMaría Ángeles Marqués-Torrejón0Charles A. C. Williams1Benjamin Southgate2Neza Alfazema3Melanie P. Clements4Claudia Garcia-Diaz5Carla Blin6Nerea Arranz-Emparan7Jane Fraser8Noor Gammoh9Simona Parrinello10Steven M. Pollard11MRC Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, University of EdinburghMRC Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, University of EdinburghMRC Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, University of EdinburghMRC Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, University of EdinburghSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, University College LondonSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, University College LondonMRC Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, University of EdinburghMRC Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, University of EdinburghCancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of EdinburghCancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of EdinburghSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, University College LondonMRC Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, University of EdinburghHow neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.https://doi.org/10.1038/s41467-021-22813-w
collection DOAJ
language English
format Article
sources DOAJ
author María Ángeles Marqués-Torrejón
Charles A. C. Williams
Benjamin Southgate
Neza Alfazema
Melanie P. Clements
Claudia Garcia-Diaz
Carla Blin
Nerea Arranz-Emparan
Jane Fraser
Noor Gammoh
Simona Parrinello
Steven M. Pollard
spellingShingle María Ángeles Marqués-Torrejón
Charles A. C. Williams
Benjamin Southgate
Neza Alfazema
Melanie P. Clements
Claudia Garcia-Diaz
Carla Blin
Nerea Arranz-Emparan
Jane Fraser
Noor Gammoh
Simona Parrinello
Steven M. Pollard
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
Nature Communications
author_facet María Ángeles Marqués-Torrejón
Charles A. C. Williams
Benjamin Southgate
Neza Alfazema
Melanie P. Clements
Claudia Garcia-Diaz
Carla Blin
Nerea Arranz-Emparan
Jane Fraser
Noor Gammoh
Simona Parrinello
Steven M. Pollard
author_sort María Ángeles Marqués-Torrejón
title LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_short LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_full LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_fullStr LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_full_unstemmed LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_sort lrig1 is a gatekeeper to exit from quiescence in adult neural stem cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.
url https://doi.org/10.1038/s41467-021-22813-w
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