In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine

In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine

Backgrounds and AimsRecently, a growing number of hepatotoxicity cases aroused by Traditional Chinese Medicine (TCM) have been reported, causing increasing concern. To date, the reported predictive models for drug induced liver injury show low prediction accuracy and there are still no related repor...

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Bibliographic Details
Main Authors: Qihui Wu, Chuipu Cai, Pengfei Guo, Meiling Chen, Xiaoqin Wu, Jingwei Zhou, Yunxia Luo, Yidan Zou, Ai-lin Liu, Qi Wang, Zaoyuan Kuang, Jiansong Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
herb induced liver injury
consensus model
traditional chinese medicine
hepatotoxicity mechanism
in silico
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00458/full

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