Eletrodos modificados com DNA: uma nova alternativa em eletroanálise

• Main Authors: La-Scalea Mauro A., Serrano Silvia H. P., Gutz Ivano G. R.
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 1999-01-01
• Series: Química Nova
• Subjects: DNA electrochemistry; DNA modified electrodes; DNA biosensors
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000300021

The first studies about DNA electrochemistry appeared at the end of the fifties. The voltammetric techniques became important tool for the DNA conformational analysis, producing evidences about DNA double helix polimorphism. The new techniques based on electrodes modification with nucleic acid enlarged the use of the electrochemical methods on the DNA research. DNA electrochemical biosensors are able to detect specific sequences of DNA bases, becoming important alternative for the diagnosis of disease, as well as in the carcinogenic species determination. Besides, the use of DNA biosensors in the mechanism study of biological drug actions can be useful for drug design.