Targeting NRF2 for the Treatment of Friedreich’s Ataxia: A Comparison among Drugs

Targeting NRF2 for the Treatment of Friedreich’s Ataxia: A Comparison among Drugs

NRF2 (Nuclear factor Erythroid 2-related Factor 2) signaling is impaired in Friedreich’s Ataxia (FRDA), an autosomal recessive disease characterized by progressive nervous system damage and degeneration of nerve fibers in the spinal cord and peripheral nerves. The loss of frataxin in patie...

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Bibliographic Details
Main Authors: Sara Petrillo, Jessica D’Amico, Piergiorgio La Rosa, Enrico Silvio Bertini, Fiorella Piemonte
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
friedreich’s ataxia
nrf2
redox active drugs
neurodegenerative disease
frataxin
Online Access:https://www.mdpi.com/1422-0067/20/20/5211

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https://www.mdpi.com/1422-0067/20/20/5211

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