Crocin Improves Endothelial Mitochondrial Dysfunction via GPx1/ROS/KCa3.1 Signal Axis in Diabetes

Crocin Improves Endothelial Mitochondrial Dysfunction via GPx1/ROS/KCa3.1 Signal Axis in Diabetes

Mitochondrial dysfunction contributes to excessive reactive oxygen species (ROS) generation, which is a dramatic cause to promote endothelial dysfunction in diabetes. It was previously demonstrated that crocin protected the endothelium based on its diverse medicinal properties, but its effect on the...

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Bibliographic Details
Main Authors: Xuemei Li, Yang Liu, Anqiang Cao, Chao Li, Luodan Wang, Qing Wu, Xinlei Li, Xiaohong Lv, Jiwei Zhu, Hua Chun, Ciren Laba, Xingchi Du, Yafang Zhang, Huike Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mitochondrial function
intermediate-conductance Ca2+ -activated K+ channels
endothelial dysfunction
crocin
diabetes mellitus
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.651434/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.651434/full

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