Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response

Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response

Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform α-syn-98 is generated by excision of exon-3 and exon-5 of the α-syn...

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Bibliographic Details
Main Authors: Tingfu Du, Zhengcun Wu, Haiyu Luo, Shuaiyao Lu, Kaili Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
α-syn-98 aggregates
Parkinson’s disease
α-syn pathology
gliosis
inflammatory response
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00189/full

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