Evidence for Oxidative Stress in Experimental Prion Disease

Evidence for Oxidative Stress in Experimental Prion Disease

Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as mar...

Full description

Bibliographic Details
Main Authors: Marin Guentchev, Till Voigtländer, Christine Haberler, Martin H. Groschup, Herbert Budka
Format: Article
Language:English
Published: Elsevier 2000-08-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100902900
id doaj-3dd0cf4e16f4492aaa031fe119fca5c7
record_format Article
spelling doaj-3dd0cf4e16f4492aaa031fe119fca5c72021-03-20T04:46:25ZengElsevierNeurobiology of Disease1095-953X2000-08-0174270273Evidence for Oxidative Stress in Experimental Prion DiseaseMarin Guentchev0Till Voigtländer1Christine Haberler2Martin H. Groschup3Herbert Budka4Austrian Reference Center for Human Prion Diseases and Institute of Neurology, University of Vienna, A-1097, Vienna, Austria; Federal Research Center for Virus Diseases of Animals, Tübingen, GermanyAustrian Reference Center for Human Prion Diseases and Institute of Neurology, University of Vienna, A-1097, Vienna, Austria; Federal Research Center for Virus Diseases of Animals, Tübingen, GermanyAustrian Reference Center for Human Prion Diseases and Institute of Neurology, University of Vienna, A-1097, Vienna, Austria; Federal Research Center for Virus Diseases of Animals, Tübingen, GermanyAustrian Reference Center for Human Prion Diseases and Institute of Neurology, University of Vienna, A-1097, Vienna, Austria; Federal Research Center for Virus Diseases of Animals, Tübingen, GermanyAustrian Reference Center for Human Prion Diseases and Institute of Neurology, University of Vienna, A-1097, Vienna, Austria; Federal Research Center for Virus Diseases of Animals, Tübingen, GermanyOxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.http://www.sciencedirect.com/science/article/pii/S0969996100902900
collection DOAJ
language English
format Article
sources DOAJ
author Marin Guentchev
Till Voigtländer
Christine Haberler
Martin H. Groschup
Herbert Budka
spellingShingle Marin Guentchev
Till Voigtländer
Christine Haberler
Martin H. Groschup
Herbert Budka
Evidence for Oxidative Stress in Experimental Prion Disease
Neurobiology of Disease
author_facet Marin Guentchev
Till Voigtländer
Christine Haberler
Martin H. Groschup
Herbert Budka
author_sort Marin Guentchev
title Evidence for Oxidative Stress in Experimental Prion Disease
title_short Evidence for Oxidative Stress in Experimental Prion Disease
title_full Evidence for Oxidative Stress in Experimental Prion Disease
title_fullStr Evidence for Oxidative Stress in Experimental Prion Disease
title_full_unstemmed Evidence for Oxidative Stress in Experimental Prion Disease
title_sort evidence for oxidative stress in experimental prion disease
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2000-08-01
description Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.
url http://www.sciencedirect.com/science/article/pii/S0969996100902900
work_keys_str_mv AT maringuentchev evidenceforoxidativestressinexperimentalpriondisease
AT tillvoigtlander evidenceforoxidativestressinexperimentalpriondisease
AT christinehaberler evidenceforoxidativestressinexperimentalpriondisease
AT martinhgroschup evidenceforoxidativestressinexperimentalpriondisease
AT herbertbudka evidenceforoxidativestressinexperimentalpriondisease
_version_ 1724212219848163328

Similar Items