Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children

Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children import...

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Main Author:	Raili Riikonen
Format:	Article
Language:	English
Published:	MDPI AG 2017-09-01
Series:	International Journal of Molecular Sciences
Subjects:	insulin-like growth factor pathogenesis neonates neurodevelopmental disorders neurodegeneration neuroprotection children
Online Access:	https://www.mdpi.com/1422-0067/18/10/2056

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spelling	doaj-3dced45fa6bf4227a0cb368caae461392020-11-24T20:47:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-09-011810205610.3390/ijms18102056ijms18102056Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in ChildrenRaili Riikonen0Child Neurology, Children’s Hospital, University of Eastern Finland and Kuopio University Hospital, P.O. Box 1627, FI-70211 Kuopio, FinlandInsulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children important? What clinical studies in neonatal asphyxia, infantile spasms, progressive encephalopathy–hypsarrhythmia–optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autistic spectrum disorders (ASD) and subacute sclerosing encephalopathy (SSPE) have been carried out? What are IGF-based therapeutic strategies? What are the therapeutic approaches? We conclude that there are now great hopes for the therapeutic use of IGF-1 for some neurological disorders (particularly ASD).https://www.mdpi.com/1422-0067/18/10/2056insulin-like growth factorpathogenesisneonatesneurodevelopmental disordersneurodegenerationneuroprotectionchildren
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Raili Riikonen
spellingShingle	Raili Riikonen Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children International Journal of Molecular Sciences insulin-like growth factor pathogenesis neonates neurodevelopmental disorders neurodegeneration neuroprotection children
author_facet	Raili Riikonen
author_sort	Raili Riikonen
title	Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children
title_short	Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children
title_full	Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children
title_fullStr	Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children
title_full_unstemmed	Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children
title_sort	insulin-like growth factors in the pathogenesis of neurological diseases in children
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2017-09-01
description	Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children important? What clinical studies in neonatal asphyxia, infantile spasms, progressive encephalopathy–hypsarrhythmia–optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autistic spectrum disorders (ASD) and subacute sclerosing encephalopathy (SSPE) have been carried out? What are IGF-based therapeutic strategies? What are the therapeutic approaches? We conclude that there are now great hopes for the therapeutic use of IGF-1 for some neurological disorders (particularly ASD).
topic	insulin-like growth factor pathogenesis neonates neurodevelopmental disorders neurodegeneration neuroprotection children
url	https://www.mdpi.com/1422-0067/18/10/2056
work_keys_str_mv	AT railiriikonen insulinlikegrowthfactorsinthepathogenesisofneurologicaldiseasesinchildren
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Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children

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