Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy
Recent evidence suggests that myeloid cells are critical in cancer development and therapy resistance processes. Pharmacological targeting of tumor-associated myeloid cells is an emerging approach among upcoming immune therapies. Surprisingly, myeloid cells are heterogeneous, including a subset of t...
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MDPI AG
2018-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/9/2565 |
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doaj-3dcc1d106ff24b1eb888bde721e59b752020-11-25T00:48:55ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-08-01199256510.3390/ijms19092565ijms19092565Delineating Pro-Angiogenic Myeloid Cells in Cancer TherapyBenjamin W. Johnson0Bhagelu R. Achyut1Sadanand Fulzele2Ashis K. Mondal3Ravindra Kolhe4Ali S. Arbab5Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USACancer Animal Models Shared Resource, Winship Cancer Center of Emory University, Atlanta, GA 30322, USADepartment of Orthopedics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USADepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USADepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USATumor Angiogenesis Laboratory, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USARecent evidence suggests that myeloid cells are critical in cancer development and therapy resistance processes. Pharmacological targeting of tumor-associated myeloid cells is an emerging approach among upcoming immune therapies. Surprisingly, myeloid cells are heterogeneous, including a subset of the myeloid cell displaying angiogenic properties in solid tumors. There is an urgent need to delineate angiogenic myeloid cell populations in order to facilitate specific targeting of protumor myeloid cells among heterogeneous pool. This review article is intended to compile all the relevant information in the literature for improved understanding of angiogenic myeloid cells and their role in tumor refractoriness to cancer therapy.http://www.mdpi.com/1422-0067/19/9/2565angiogenicmyeloidchemotherapyradiotherapyimmunotherapyantiangiogenicMDSCtumor |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Benjamin W. Johnson Bhagelu R. Achyut Sadanand Fulzele Ashis K. Mondal Ravindra Kolhe Ali S. Arbab |
| spellingShingle |
Benjamin W. Johnson Bhagelu R. Achyut Sadanand Fulzele Ashis K. Mondal Ravindra Kolhe Ali S. Arbab Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy International Journal of Molecular Sciences angiogenic myeloid chemotherapy radiotherapy immunotherapy antiangiogenic MDSC tumor |
| author_facet |
Benjamin W. Johnson Bhagelu R. Achyut Sadanand Fulzele Ashis K. Mondal Ravindra Kolhe Ali S. Arbab |
| author_sort |
Benjamin W. Johnson |
| title |
Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy |
| title_short |
Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy |
| title_full |
Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy |
| title_fullStr |
Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy |
| title_full_unstemmed |
Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy |
| title_sort |
delineating pro-angiogenic myeloid cells in cancer therapy |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2018-08-01 |
| description |
Recent evidence suggests that myeloid cells are critical in cancer development and therapy resistance processes. Pharmacological targeting of tumor-associated myeloid cells is an emerging approach among upcoming immune therapies. Surprisingly, myeloid cells are heterogeneous, including a subset of the myeloid cell displaying angiogenic properties in solid tumors. There is an urgent need to delineate angiogenic myeloid cell populations in order to facilitate specific targeting of protumor myeloid cells among heterogeneous pool. This review article is intended to compile all the relevant information in the literature for improved understanding of angiogenic myeloid cells and their role in tumor refractoriness to cancer therapy. |
| topic |
angiogenic myeloid chemotherapy radiotherapy immunotherapy antiangiogenic MDSC tumor |
| url |
http://www.mdpi.com/1422-0067/19/9/2565 |
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