A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 µM against acet...

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Bibliographic Details
Main Authors:	Abdulrahman I. Almansour, Raju Suresh Kumar, Natarajan Arumugam, Alireza Basiri, Yalda Kia, Mohamed Ashraf Ali, Mehvish Farooq, Vikneswaran Murugaiyah
Format:	Article
Language:	English
Published:	MDPI AG 2015-01-01
Series:	Molecules
Subjects:	acetylcholinesterase (AChE), butyrylcholinesterase (BChE), Alzheimer’s disease (AD), spiropyrrolidines, ionic liquid and molecular docking study
Online Access:	http://www.mdpi.com/1420-3049/20/2/2296

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