The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications

The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications

Magnesium alloys have gained great attention as biodegradable materials for stent applications. Cardiovascular stents are continuously exposed to different types of mechanical loadings simultaneously during service, including tensile, compressive and fluid shear stress. In this study, the in vitro d...

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Main Authors: Xue-Nan Gu, Yun Lu, Fan Wang, Wenting Lin, Ping Li, Yubo Fan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-12-01
Series:Bioactive Materials
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X18300513
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spelling doaj-3dc66909702e450baa5392c41ce9aef72021-02-02T03:41:48ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2018-12-0134448454The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applicationsXue-Nan Gu0Yun Lu1Fan Wang2Wenting Lin3Ping Li4Yubo Fan5Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 10083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 102402, China; Corresponding author. School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 10083, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 10083, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 10083, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 10083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 102402, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 10083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 102402, China; National Research Center for Rehabilitation Technical Aids, Beijing, 100176, China; Corresponding author. School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.Magnesium alloys have gained great attention as biodegradable materials for stent applications. Cardiovascular stents are continuously exposed to different types of mechanical loadings simultaneously during service, including tensile, compressive and fluid shear stress. In this study, the in vitro degradation of WE43 wires was investigated under combined effect of tensile loading and fluid shear stress and compared with that experienced an individual loading condition. For the individual mechanical loading treatment, the degradation of magnesium wires was more severely affected by tensile loading than fluid shear stress. Under tensile loading, magnesium wires showed faster increment of corrosion rates, loss of mechanical properties and localized corrosion morphology with the increasing tensile loadings. With the combined stress, smaller variation of the corrosion rates as well as the slower strength degeneration was shown with increasing stress levels, in comparison with the individual treatment of tensile loading. This study could help to understand the effect of complex stress condition on the corrosion of magnesium for the optimization of biodegradable magnesium stents. Keywords: Magnesium alloys, Degradation, Stent, Stresshttp://www.sciencedirect.com/science/article/pii/S2452199X18300513
collection DOAJ
language English
format Article
sources DOAJ
author Xue-Nan Gu
Yun Lu
Fan Wang
Wenting Lin
Ping Li
Yubo Fan
spellingShingle Xue-Nan Gu
Yun Lu
Fan Wang
Wenting Lin
Ping Li
Yubo Fan
The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications
Bioactive Materials
author_facet Xue-Nan Gu
Yun Lu
Fan Wang
Wenting Lin
Ping Li
Yubo Fan
author_sort Xue-Nan Gu
title The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications
title_short The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications
title_full The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications
title_fullStr The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications
title_full_unstemmed The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications
title_sort effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications
publisher KeAi Communications Co., Ltd.
series Bioactive Materials
issn 2452-199X
publishDate 2018-12-01
description Magnesium alloys have gained great attention as biodegradable materials for stent applications. Cardiovascular stents are continuously exposed to different types of mechanical loadings simultaneously during service, including tensile, compressive and fluid shear stress. In this study, the in vitro degradation of WE43 wires was investigated under combined effect of tensile loading and fluid shear stress and compared with that experienced an individual loading condition. For the individual mechanical loading treatment, the degradation of magnesium wires was more severely affected by tensile loading than fluid shear stress. Under tensile loading, magnesium wires showed faster increment of corrosion rates, loss of mechanical properties and localized corrosion morphology with the increasing tensile loadings. With the combined stress, smaller variation of the corrosion rates as well as the slower strength degeneration was shown with increasing stress levels, in comparison with the individual treatment of tensile loading. This study could help to understand the effect of complex stress condition on the corrosion of magnesium for the optimization of biodegradable magnesium stents. Keywords: Magnesium alloys, Degradation, Stent, Stress
url http://www.sciencedirect.com/science/article/pii/S2452199X18300513
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