Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam

Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of al...

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Main Authors:	A. Schimmenti, E. Brunetti, E. Seminari, B. Mariani, P. Cambieri, P. Orsolini
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Case Reports in Infectious Diseases
Online Access:	http://dx.doi.org/10.1155/2018/1854805

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spelling	doaj-3dc45b3d145c4a03b4a0ff6669ed5fa02020-11-24T21:12:36ZengHindawi LimitedCase Reports in Infectious Diseases2090-66252090-66332018-01-01201810.1155/2018/18548051854805Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-AvibactamA. Schimmenti0E. Brunetti1E. Seminari2B. Mariani3P. Cambieri4P. Orsolini5Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Unità di Malattie Infettive e Tropicali ed Epatologia, Università di Pavia, Pavia, ItalyDipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Unità di Malattie Infettive e Tropicali ed Epatologia, Università di Pavia, Pavia, ItalyUnità di Malattie Infettive e Tropicali, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyMicrobiologia e Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyMicrobiologia e Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyUnità di Malattie Infettive e Tropicali, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyAntimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the first case of a patient with a prosthetic joint infection from carbapenemase-resistant Klebsiella pneumoniae (CRKP) successfully treated with ceftazidime-avibactam in Italy.http://dx.doi.org/10.1155/2018/1854805
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	A. Schimmenti E. Brunetti E. Seminari B. Mariani P. Cambieri P. Orsolini
spellingShingle	A. Schimmenti E. Brunetti E. Seminari B. Mariani P. Cambieri P. Orsolini Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam Case Reports in Infectious Diseases
author_facet	A. Schimmenti E. Brunetti E. Seminari B. Mariani P. Cambieri P. Orsolini
author_sort	A. Schimmenti
title	Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_short	Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_full	Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_fullStr	Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_full_unstemmed	Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_sort	prosthetic joint infection from carbapenemase-resistant klebsiella pneumoniae successfully treated with ceftazidime-avibactam
publisher	Hindawi Limited
series	Case Reports in Infectious Diseases
issn	2090-6625 2090-6633
publishDate	2018-01-01
description	Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the first case of a patient with a prosthetic joint infection from carbapenemase-resistant Klebsiella pneumoniae (CRKP) successfully treated with ceftazidime-avibactam in Italy.
url	http://dx.doi.org/10.1155/2018/1854805
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Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam

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