The cellular prion protein: a player in immunological quiescence

The cellular prion protein: a player in immunological quiescence

Despite intensive studies since the 1990s, the physiological role of the cellular prion protein (PrPC) remains elusive. Here, we present a novel concept suggesting that PrPC contributes to immunological quiescence in addition to cell protection. PrPC is highly expressed in diverse organs that by mul...

Full description

Bibliographic Details
Main Authors:	Maren Kolltveit Bakkebø, Sophie eMouillet-Richard, Arild Espenes Espenes, Wilfred eGoldmann, Jörg eTatzelt, Michael Andreas Tranulis
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-09-01
Series:	Frontiers in Immunology
Subjects:	Cytoprotection Inflammation Alzheimer prion protein neurodegeneration Cell signaling
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00450/full

Similar Items

Hematological shift in goat kids naturally devoid of prion protein
by: Malin Rokseth Reiten, et al.
Published: (2015-07-01)

Goats without Prion Protein Display Enhanced Proinflammatory Pulmonary Signaling and Extracellular Matrix Remodeling upon Systemic Lipopolysaccharide Challenge
by: Øyvind Salvesen, et al.
Published: (2017-12-01)

N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases
by: Hideyuki Hara, et al.
Published: (2020-08-01)

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration
by: Carlo Scialò, et al.
Published: (2019-03-01)

LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface
by: Ø. Salvesen, et al.
Published: (2017-05-01)

Prions, prion-like prionoids, and neurodegenerative disordersVacancy
by: Ashok Verma
Published: (2016-01-01)

Biological Functions of the Intrinsically Disordered N-Terminal Domain of the Prion Protein: A Possible Role of Liquid–Liquid Phase Separation
by: Stella A. Polido, et al.
Published: (2021-08-01)

Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106
by: Keiji Uchiyama, et al.
Published: (2020-10-01)

Enhanced neuroinvasion by smaller, soluble prions
by: Cyrus Bett, et al.
Published: (2017-04-01)

Prion diseases: fatal familial insomnia
by: Barbara Madoń, et al.
Published: (2021-09-01)

A New Cell Model for Investigating Prion Strain Selection and Adaptation
by: Alexandra Philiastides, et al.
Published: (2019-09-01)

Interaction between Hemin and Prion Peptides: Binding, Oxidative Reactivity and Aggregation
by: Simone Dell’Acqua, et al.
Published: (2020-10-01)

Hijacking PrPC-dependent signal transduction: when prions impair Αβ clearance
by: Julia eHernandez-Rapp, et al.
Published: (2014-02-01)

Prion protein in myelin maintenance: what does the goat say?
by: Fredrik S Skedsmo, et al.
Published: (2021-01-01)

Rôle de la protéine prion cellulaire (PRPC) dans la différenciation neuronale : Infection par les prions (PRPSC) et bases moléculaires de la neurodégénérescence
by: Dakowski, Caroline
Published: (2012)

Prions and Prion-Like Pathogens in Neurodegenerative Disorders
by: Caterina Peggion, et al.
Published: (2014-02-01)

To Develop With Or Without The Prion Protein
by: Sophie eHalliez, et al.
Published: (2014-10-01)

Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein
by: Brent Race, et al.
Published: (2020-10-01)

From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins
by: Cristóbal Marrero-Winkens, et al.
Published: (2020-09-01)

Approaches to therapy against prion diseases focused on the individual defence system
by: Marta Monzón
Published: (2017-07-01)

Loss of PIKfyve drives the spongiform degeneration in prion diseases
by: Asvin K K Lakkaraju, et al.
Published: (2021-09-01)

Chronic Progressive Neurodegeneration in a transgenic mouse model of Prion disease
by: Nina Fainstein, et al.
Published: (2016-11-01)

Prion peptide-mediated calcium level alteration governs neuronal cell damage through AMPK-autophagy flux
by: Ji-Hong Moon, et al.
Published: (2020-07-01)

The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses
by: Asad Jan, et al.
Published: (2021-08-01)

Stress Resilience of Spermatozoa and Blood Mononuclear Cells without Prion Protein
by: Malin R. Reiten, et al.
Published: (2018-01-01)

Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons
by: Claudia Scheckel, et al.
Published: (2020-09-01)

A systematic investigation of production of synthetic prions from recombinant prion protein
by: Christian Schmidt, et al.
Published: (2015-01-01)

The sheddase ADAM10 is a potent modulator of prion disease
by: Hermann C Altmeppen, et al.
Published: (2015-02-01)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
by: Antonio Heras-Garvin, et al.
Published: (2020-09-01)

Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux
by: Marcio Henrique Mello da Luz, et al.
Published: (2015-02-01)

Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
by: Natallia Makarava, et al.
Published: (2018-09-01)

Regulation of a prion-induced immune response by miRNA-146a
by: Gushue, Shantel
Published: (2014)

Is Multiple System Atrophy a Prion-like Disorder?
by: Kurt A. Jellinger, et al.
Published: (2021-09-01)

The Prion protein family: a view from the placenta
by: Samira eMakhzami, et al.
Published: (2014-08-01)

PMCA Applications for Prion Detection in Peripheral Tissues of Patients with Variant Creutzfeldt-Jakob Disease
by: Giorgio Giaccone, et al.
Published: (2020-03-01)

Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death
by: F.J. Fernandez-Gomez, et al.
Published: (2005-11-01)

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils
by: Cassandra Terry, et al.
Published: (2016-01-01)

Understanding the role of MiR-16-5p in prion-induced neurodegeneration
by: Burak, Kristyn
Published: (2017)

Spongiform pathology in mouse CNS lacking ‘neuropathy target esterase’ and cellular prion protein
by: Jack Rosenbluth, et al.
Published: (2009-09-01)

Selective vulnerability to neurodegenerative disease: the curious case of Prion Protein
by: Walker S. Jackson
Published: (2014-01-01)