Development and Validation Results of the Russian MPN10 Form for Symptom Assessment in Patients with Myeloproliferative Neoplasms Compliant with International Recommendations

• Main Authors: TI Ionova, OYu Vinogradova, EV Efremova, AE Kersilova, TP Nikitina, MM Pankrashkina, NM Porfir’eva, A-PA Poshivai, MS Fominykh, DI Shikhbabaeva, VA Shuvaev
• Format: Article
• Language: Russian
• Published: Practical Medicine Publishing House 2019-03-01
• Series: Kliničeskaâ onkogematologiâ
• Subjects: symptom assessment form; myeloproliferative neoplasms; psychometric properties of the form; validation
• Online Access: http://bloodjournal.ru/wp-content/uploads/2020/03/8.pdf

Aim. To develop a Russian version of MPN10 form for patients with myeloproliferative neoplasms (MPN) compliant with international recommendations. Materials & Methods. The trial included 57 patients treated in 2019 at the Moscow Municipal Center for Hematology of the SP Botkin Clinical Hospital (n = 30) and the Russian Research Institute of Hematology and Transfusiology (n = 27). Among them there were 36 myelofibrosis, 9 polycythemia vera, and 12 essential thrombocythemia patients. Mean age of the patients was 54.6 years (standard deviation 15.9 years; age range 20–79 years). The male/female ratio was 23/34 (40.4 %/59.6 %). Underlying disease duration was from 1 month to 33 years (mean duration 7 years; standard deviation 8.6 years). Results. A stable structure and a high inner consistency of the form as well as its reproducibility as a tool were demonstrated. The trial also confirmed its convergent and discriminant validity and satisfactory sensitivity to changes in a patient’s status. Conclusion. The Russian MPN10 version can be used for symptom assessment in MPN patients in clinical practice and scientific research.