Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

Despite its wide and growing use, the mechanisms by which in vivo vagus nerve stimulation (VNS) exerts its therapeutic benefits are still largely unknown. Here, the authors show in mice that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by...

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Bibliographic Details
Main Authors: Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21730-2

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