Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice

In response to environmental threats, such as visual looming stimuli, mice either freeze or escape. Here the authors demonstrate that these two behaviors are mediated by separate tectofugal pathways formed by parvalbumin-positive neurons in the superior colliculus.

Bibliographic Details
Main Authors:	Congping Shang, Zijun Chen, Aixue Liu, Yang Li, Jiajing Zhang, Baole Qu, Fei Yan, Yaning Zhang, Weixiu Liu, Zhihui Liu, Xiaofei Guo, Dapeng Li, Yi Wang, Peng Cao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03580-7

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spelling	doaj-3daefd7ae4da4c9d9f34367b21bccda92021-05-11T09:41:01ZengNature Publishing GroupNature Communications2041-17232018-03-019111710.1038/s41467-018-03580-7Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in miceCongping Shang0Zijun Chen1Aixue Liu2Yang Li3Jiajing Zhang4Baole Qu5Fei Yan6Yaning Zhang7Weixiu Liu8Zhihui Liu9Xiaofei Guo10Dapeng Li11Yi Wang12Peng Cao13State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesNational Institute of Biological SciencesNational Institute of Biological SciencesState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesPTN Graduate Programs, School of Life Sciences, Tsinghua UniversityPTN Graduate Programs, School of Life Sciences, Tsinghua UniversityState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesNational Institute of Biological SciencesState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of SciencesIn response to environmental threats, such as visual looming stimuli, mice either freeze or escape. Here the authors demonstrate that these two behaviors are mediated by separate tectofugal pathways formed by parvalbumin-positive neurons in the superior colliculus.https://doi.org/10.1038/s41467-018-03580-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Congping Shang Zijun Chen Aixue Liu Yang Li Jiajing Zhang Baole Qu Fei Yan Yaning Zhang Weixiu Liu Zhihui Liu Xiaofei Guo Dapeng Li Yi Wang Peng Cao
spellingShingle	Congping Shang Zijun Chen Aixue Liu Yang Li Jiajing Zhang Baole Qu Fei Yan Yaning Zhang Weixiu Liu Zhihui Liu Xiaofei Guo Dapeng Li Yi Wang Peng Cao Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice Nature Communications
author_facet	Congping Shang Zijun Chen Aixue Liu Yang Li Jiajing Zhang Baole Qu Fei Yan Yaning Zhang Weixiu Liu Zhihui Liu Xiaofei Guo Dapeng Li Yi Wang Peng Cao
author_sort	Congping Shang
title	Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
title_short	Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
title_full	Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
title_fullStr	Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
title_full_unstemmed	Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
title_sort	divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	In response to environmental threats, such as visual looming stimuli, mice either freeze or escape. Here the authors demonstrate that these two behaviors are mediated by separate tectofugal pathways formed by parvalbumin-positive neurons in the superior colliculus.
url	https://doi.org/10.1038/s41467-018-03580-7
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Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice

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