Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives

A series of pyrimidine and thiazine derivatives synthesized by one pot reaction of cyclopentanone with a mixture of an aromatic aldehyde namely o-anisaldehyde and different ureas namely urea, guanidine and thiourea, respectively. Furthermore, cycloaddition reaction of active methylene reagents namel...

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Main Authors:	Essam A. Soylem, Mohammed G. Assy, Ghania M Morsi
Format:	Article
Language:	English
Published:	Slovenian Chemical Society 2016-07-01
Series:	Acta Chimica Slovenica
Subjects:	Cyclopentapyrimidine Thiazolopyrimidine Quinazoline Chromene Antitumor activity
Online Access:	https://journals.matheo.si/index.php/ACSi/article/view/2297

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spelling	doaj-3da3169b45774a3c8e78aedb749026b42020-11-25T01:59:35ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552016-07-0163360961810.17344/acsi.2016.2297377Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivativesEssam A. Soylem0Mohammed G. Assy1Ghania M Morsi2Department of Chemistry, Faculty of Science, Zagazig University, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, EgyptA series of pyrimidine and thiazine derivatives synthesized by one pot reaction of cyclopentanone with a mixture of an aromatic aldehyde namely o-anisaldehyde and different ureas namely urea, guanidine and thiourea, respectively. Furthermore, cycloaddition reaction of active methylene reagents namely acetyl acetone, malononitrile, ethyl cyanoacetate, cyanoacetamide and N-phenyl cyanoacetamide with 2,6-bis(2-methoxybenzylidene)-cyclohexanone afforded chromene and quinoline derivatives in basic medium. The antitumor evaluation of some new compounds against three human cell lines namely MCF-7, NCI-H460 and SF-268 showed significant and moderate activity compared with the positive control doxorubicin.https://journals.matheo.si/index.php/ACSi/article/view/2297CyclopentapyrimidineThiazolopyrimidineQuinazolineChromeneAntitumor activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Essam A. Soylem Mohammed G. Assy Ghania M Morsi
spellingShingle	Essam A. Soylem Mohammed G. Assy Ghania M Morsi Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives Acta Chimica Slovenica Cyclopentapyrimidine Thiazolopyrimidine Quinazoline Chromene Antitumor activity
author_facet	Essam A. Soylem Mohammed G. Assy Ghania M Morsi
author_sort	Essam A. Soylem
title	Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives
title_short	Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives
title_full	Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives
title_fullStr	Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives
title_full_unstemmed	Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives
title_sort	heteroannelation of cyclic ketones: synthesis, characterization and antitumor evaluation of some condensed azine derivatives
publisher	Slovenian Chemical Society
series	Acta Chimica Slovenica
issn	1318-0207 1580-3155
publishDate	2016-07-01
description	A series of pyrimidine and thiazine derivatives synthesized by one pot reaction of cyclopentanone with a mixture of an aromatic aldehyde namely o-anisaldehyde and different ureas namely urea, guanidine and thiourea, respectively. Furthermore, cycloaddition reaction of active methylene reagents namely acetyl acetone, malononitrile, ethyl cyanoacetate, cyanoacetamide and N-phenyl cyanoacetamide with 2,6-bis(2-methoxybenzylidene)-cyclohexanone afforded chromene and quinoline derivatives in basic medium. The antitumor evaluation of some new compounds against three human cell lines namely MCF-7, NCI-H460 and SF-268 showed significant and moderate activity compared with the positive control doxorubicin.
topic	Cyclopentapyrimidine Thiazolopyrimidine Quinazoline Chromene Antitumor activity
url	https://journals.matheo.si/index.php/ACSi/article/view/2297
work_keys_str_mv	AT essamasoylem heteroannelationofcyclicketonessynthesischaracterizationandantitumorevaluationofsomecondensedazinederivatives AT mohammedgassy heteroannelationofcyclicketonessynthesischaracterizationandantitumorevaluationofsomecondensedazinederivatives AT ghaniammorsi heteroannelationofcyclicketonessynthesischaracterizationandantitumorevaluationofsomecondensedazinederivatives
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Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives

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