Impaired glucose tolerance and albuminuria in patients with chronic heart failure: a subanalysis of the SUPPORT trial

• Main Authors: Kotaro Nochioka, Yasuhiko Sakata, Masanobu Miura, Takashi Shiroto, Jun Takahashi, Chie Saga, Yasuko Ikeno, Nobuyuki Shiba, Tsuyoshi Shinozaki, Masafumi Sugi, Makoto Nakagawa, Tatsuya Komaru, Atsushi Kato, Eiji Nozaki, Kaoru Iwabuchi, Tetsuya Hiramoto, Kanichi Inoue, Masatoshi Ohe, Kenji Tamaki, Ichiro Tsuji, Hiroaki Shimokawa
• Format: Article
• Language: English
• Published: Wiley 2019-12-01
• Series: ESC Heart Failure
• Subjects: Chronic heart failure; Impaired glucose tolerance; Diabetes mellitus; Albuminuria
• Online Access: https://doi.org/10.1002/ehf2.12516

Abstract Aims The study aims to evaluate the prognostic significance of impaired glucose tolerance (IGT) with reference to albuminuria in patients with chronic heart failure (CHF). Methods and results We examined 535 CHF patients (mean 66 years, women 25%) in the control arm of our SUPPORT trial, in which we examined additive impact of olmesartan in hypertensive patients with symptomatic CHF treated with β‐blockers and/or angiotensin‐converting enzyme inhibitors. We examined the association between glycaemic abnormality (assessed by 75 g of oral glucose tolerance test) and albuminuria for a composite outcome of all‐cause death, myocardial infarction, stroke, and HF hospitalization. IGT patients (N = 113, mean 67.2 years) were older and more frequently treated with β‐blockers compared with those with normal glucose regulation (N = 142, mean 64.0 years) and those with diabetes mellitus (N = 280, mean 65.7 years). Multivariable Cox proportional hazard models revealed that, as compared with normal glucose regulation (NGR), IGT was associated with increased risk of the outcome when complicated by albuminuria [hazard ratio (HR) 2.25; 95% confidence interval (CI) 1.14–4.42; P = 0.019] but not when uncomplicated by albuminuria (HR 0.76; 95% CI 0.35–1.60, P = 0.47) (P for interaction = 0.041). This was also the case for diabetes mellitus and albuminuria (HR 2.06; 95% CI 1.17–3.61; P = 0.012). Among IGT patients without albuminuria, 21 (29%) developed albuminuria at 1‐year visit, which was again associated with poor prognosis (HR 7.36; 95% CI 1.39–38.98, P = 0.019). Conclusions These results indicate that IGT is associated with poor prognosis when complicated by albuminuria in CHF patients, demonstrating the importance of combined early stages of glucose intolerance and renal dysfunction in the management of CHF.