Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice

Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice

Fragile X Syndrome (FXS) is the most common inherited cause of intellectual disability, and is the leading known single-gene cause of autism spectrum disorder. FXS patients display varied behavioural deficits that include mild to severe cognitive impairments in addition to mood disorders. Currently...

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Bibliographic Details
Main Authors: S.Y. Yau, Luis Bettio, M. Vetrici, A. Truesdell, C. Chiu, J. Chiu, E. Truesdell, B.R. Christie
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Neurobiology of Disease
Subjects:
NMDA
Fragile X Syndrome
Minocycline
Hippocampus
Synaptic plasticity
Behaviour
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300202

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