Elucidating the Structure-Activity Relationships of the Vasorelaxation and Antioxidation Properties of Thionicotinic Acid Derivatives

Elucidating the Structure-Activity Relationships of the Vasorelaxation and Antioxidation Properties of Thionicotinic Acid Derivatives

Nicotinic acid, known as vitamin B3, is an effective lipid lowering drug and intense cutaneous vasodilator. This study reports the effect of 2-(1-adamantylthio)nicotinic acid (6) and its amide 7 and nitrile analog 8 on phenylephrine-induced contraction of rat thoracic aorta as well as antioxidative...

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Bibliographic Details
Main Authors: Virapong Prachayasittikul, Somsak Ruchirawat, Chanin Nantasenamat, Apilak Worachartcheewan, Orapin Wongsawatkul, Supaluk Prachayasittikul
Format: Article
Language:English
Published: MDPI AG 2010-01-01
Series:Molecules
Subjects:
1-adamantylthionicotinic acid and derivatives
vasorelaxants
antioxidants
nitric oxide
prostacyclin
molecular modeling
Online Access:http://www.mdpi.com/1420-3049/15/1/198/

Internet

http://www.mdpi.com/1420-3049/15/1/198/

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