Efficient in Utero Gene Transfer to the Mammalian Inner Ears by the Synthetic Adeno-Associated Viral Vector Anc80L65

Efficient in Utero Gene Transfer to the Mammalian Inner Ears by the Synthetic Adeno-Associated Viral Vector Anc80L65

Sensorineural hearing loss is one of the most common sensory disorders worldwide. Recent advances in vector design have paved the way for investigations into the use of adeno-associated vectors (AAVs) for hearing disorder gene therapy. Numerous AAV serotypes have been discovered to be applicable to...

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Bibliographic Details
Main Authors: Chin-Ju Hu, Ying-Chang Lu, Yi-Hsiu Tsai, Haw-Yuan Cheng, Hiroki Takeda, Chun-Ying Huang, Ru Xiao, Chuan-Jen Hsu, Jin-Wu Tsai, Luk H. Vandenberghe, Chen-Chi Wu, Yen-Fu Cheng
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
in utero microinjection
AAV2/Anc80L65
inner ears
gene therapy
hereditary deafness
adeno-associated virus
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301431

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