Effect of Preparations Based on Lanthanide Ions and Calcium on the Bone Density in Rats with a Femur Fracture

• Main Authors: I. F. Akhtyamov, F. V. Shakirova, D. A. Korobeynikova, Han Hao Zhi, R. I. Sadykov
• Format: Article
• Language: Russian
• Published: Vreden Russian Research Institute of Traumatology and Orthopedics 2020-03-01
• Series: Travmatologiâ i Ortopediâ Rossii
• Subjects: bone regeneration; bone density; rat femur fracture; intramedullary osteosynthesis; calcium; lanthanide ions
• Online Access: https://journal.rniito.org/jour/article/view/1326
• ISSN: 2311-2905; 2542-0933

Purpose of the study — to evaluate bone density at the femur fracture site with local introduction of preparations based on etidronate lanthanide ions and calcium in the experiment. Materials and Methods. The experiment included 45 male rats divided into three comparable groups equal in quantity. The experiment in control group was performed without stimulation of bone formation, preparation based on etidronate lanthanide ions and calcium were introduced to the animals of the first group and preparation containing etidronate and calcium (without lanthanide ions) were used in the second group. Preparation was introduced twice at the site of femoral fracture in the study groups of animals. The authors performed daily clinical monitoring and measured the density of the cortical bone at the fracture site using computer tomography. Results. Earlier support on the operated limb was observed after introduction of etidronate lanthanide ions and calcium. In the respective study group after introduction of the preparation the authors reported statistically significant 20% higher cortex density at earlier terms in contrast to the control group, and 24% higher density as compared to group with introduction of etidronates and calcium (without lanthanide ions). By day 30 cortical plate density in the group with introduction of preparation based on lanthanide ions was statistically significantly higher at 37% as compared to two other groups. Conclusion. The authors observed a positive effect of studied preparations on bone regenerate formation in rats. Data of the present research allows to conclude that periosteal introduction of preparations based on etidronate lanthanide ions and calcium at the osteotomy site provides formation of a cortical plate with improved density properties, and normalization of density indicators in the present group occurred in earlier terms that in the group with preparation based on etidronates and calcium (without lanthanide ions).