Systematic analysis of the intersection of disease mutations with protein modifications

Systematic analysis of the intersection of disease mutations with protein modifications

Abstract Background Perturbed posttranslational modification (PTM) landscapes commonly cause pathological phenotypes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors allowing the identification of spontaneous cancer-driving mutations, while Uniprot and dbSNP manage genetic diseas...

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Bibliographic Details
Main Authors: Claire M. Simpson, Bin Zhang, Peter V. Hornbeck, Florian Gnad
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Medical Genomics
Subjects:
Posttranslational modification
Cancer
Disease
PhosphoSitePlus
TCGA
dbSNP
Online Access:http://link.springer.com/article/10.1186/s12920-019-0543-2

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