Impact of Wnt/β-Catenin Inhibition on Cell Proliferation through <i>CDC25A</i> Downregulation in Soft Tissue Sarcomas

Impact of Wnt/β-Catenin Inhibition on Cell Proliferation through <i>CDC25A</i> Downregulation in Soft Tissue Sarcomas

The Wnt signaling pathway is an important cellular mechanism for regulating differentiation processes as well as cell cycle events, and different inhibitors of this pathway, for example, PRI-724, are showing promising results in clinical trials for treatment of advanced pancreatic adenocarcinoma or...

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Bibliographic Details
Main Authors: Esther Martinez-Font, Marina Pérez-Capó, Rafael Ramos, Irene Felipe, Carmen Garcías, Pablo Luna, Josefa Terrasa, Javier Martín-Broto, Oliver Vögler, Regina Alemany, Antònia Obrador-Hevia
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
soft tissue sarcoma
Wnt signaling
β-catenin
CDC25A
PRI-724
Online Access:https://www.mdpi.com/2072-6694/12/9/2556

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