Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity

Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity

(1) Background: We characterized a novel animal model with obesity-induced constipation because constipation is rarely known in genetically engineered mice (GEM); (2) Methods: The changes in the constipation parameters and mechanisms were analyzed in CRISPR-Cas9-mediated leptin (Lep) knockout (KO) m...

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Bibliographic Details
Main Authors:	Ji Eun Kim, Yun Ju Choi, Su Jin Lee, Jeong Eun Gong, Yong Lim, Jin Tae Hong, Dae Youn Hwang
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	International Journal of Molecular Sciences
Subjects:	constipation leptin knockout mice gastrointestinal motility muscle contraction mAChR
Online Access:	https://www.mdpi.com/1422-0067/21/24/9464

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