Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa

Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa

Abstract Background Holarrhena antidysenterica has been employed as an ethnobotanical plant for the treatment of dysentery, diarrhoea, fever, and bacterial infections. Biological activities of the principle compound, conessine including anti-diarrhoea and anti-plasmodial effects were documented. Our...

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Main Authors: Thanyaluck Siriyong, Potjanee Srimanote, Sasitorn Chusri, Boon-ek Yingyongnarongkul, Channarong Suaisom, Varomyalin Tipmanee, Supayang Piyawan Voravuthikunchai
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Conessine
Efflux pump inhibitor
MexAB-OprM efflux system
Pseudomonas aeruginosa
Online Access:http://link.springer.com/article/10.1186/s12906-017-1913-y

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