Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential...

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Main Authors:	Jacqueline A. Maybin, Alison A. Murray, Philippa T. K. Saunders, Nikhil Hirani, Peter Carmeliet, Hilary O. D. Critchley
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02375-6

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spelling	doaj-3d625696cf6342b79ac265446a69ab162021-05-11T09:33:57ZengNature Publishing GroupNature Communications2041-17232018-01-019111310.1038/s41467-017-02375-6Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruationJacqueline A. Maybin0Alison A. Murray1Philippa T. K. Saunders2Nikhil Hirani3Peter Carmeliet4Hilary O. D. Critchley5MRC Centre for Reproductive Health, The Queen’s Medical Research Centre, The University of EdinburghMRC Centre for Reproductive Health, The Queen’s Medical Research Centre, The University of EdinburghMRC Centre for Inflammation Research, The Queen’s Medical Research Centre, The University of EdinburghMRC Centre for Inflammation Research, The Queen’s Medical Research Centre, The University of EdinburghLaboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, Centre for Cancer Biology, KU LeuvenMRC Centre for Reproductive Health, The Queen’s Medical Research Centre, The University of EdinburghAbout a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential therapeutic strategy for this debilitating condition.https://doi.org/10.1038/s41467-017-02375-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jacqueline A. Maybin Alison A. Murray Philippa T. K. Saunders Nikhil Hirani Peter Carmeliet Hilary O. D. Critchley
spellingShingle	Jacqueline A. Maybin Alison A. Murray Philippa T. K. Saunders Nikhil Hirani Peter Carmeliet Hilary O. D. Critchley Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation Nature Communications
author_facet	Jacqueline A. Maybin Alison A. Murray Philippa T. K. Saunders Nikhil Hirani Peter Carmeliet Hilary O. D. Critchley
author_sort	Jacqueline A. Maybin
title	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_short	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_full	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_fullStr	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_full_unstemmed	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_sort	hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential therapeutic strategy for this debilitating condition.
url	https://doi.org/10.1038/s41467-017-02375-6
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Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

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