Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense

Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense

The eosinophil-derived neurotoxin (EDN/RNase2) and its divergent orthologs, the mouse eosinophil-associated RNases (mEars), are prominent secretory proteins of eosinophilic leukocytes and are all members of the larger family of RNase A-type ribonucleases. While EDN has broad antiviral activity, targ...

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Bibliographic Details
Main Author: Helene F. Rosenberg
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
inflammation
leukocyte
evolution
chemoattractant
Online Access:http://www.mdpi.com/1422-0067/16/7/15442

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