The Endocannabinoid System: A Target for Cancer Treatment

The Endocannabinoid System: A Target for Cancer Treatment

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However...

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Main Authors: Chiara Laezza, Cristina Pagano, Giovanna Navarra, Olga Pastorino, Maria Chiara Proto, Donatella Fiore, Chiara Piscopo, Patrizia Gazzerro, Maurizio Bifulco
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
cannabinoids
metastasis
cancer stem cell
angiogenesis
Online Access:https://www.mdpi.com/1422-0067/21/3/747
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spelling doaj-3d4d906b33804080aa8ae4874b9e73ab2020-11-25T01:30:14ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-01-0121374710.3390/ijms21030747ijms21030747The Endocannabinoid System: A Target for Cancer TreatmentChiara Laezza0Cristina Pagano1Giovanna Navarra2Olga Pastorino3Maria Chiara Proto4Donatella Fiore5Chiara Piscopo6Patrizia Gazzerro7Maurizio Bifulco8Institute of Endocrinology and Experimental Oncology, IEOS CNR, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano (SA), ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano (SA), ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano (SA), ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano (SA), ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, 80131 Naples, ItalyIn recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.https://www.mdpi.com/1422-0067/21/3/747cannabinoidsmetastasiscancer stem cellangiogenesis
collection DOAJ
language English
format Article
sources DOAJ
author Chiara Laezza
Cristina Pagano
Giovanna Navarra
Olga Pastorino
Maria Chiara Proto
Donatella Fiore
Chiara Piscopo
Patrizia Gazzerro
Maurizio Bifulco
spellingShingle Chiara Laezza
Cristina Pagano
Giovanna Navarra
Olga Pastorino
Maria Chiara Proto
Donatella Fiore
Chiara Piscopo
Patrizia Gazzerro
Maurizio Bifulco
The Endocannabinoid System: A Target for Cancer Treatment
International Journal of Molecular Sciences
cannabinoids
metastasis
cancer stem cell
angiogenesis
author_facet Chiara Laezza
Cristina Pagano
Giovanna Navarra
Olga Pastorino
Maria Chiara Proto
Donatella Fiore
Chiara Piscopo
Patrizia Gazzerro
Maurizio Bifulco
author_sort Chiara Laezza
title The Endocannabinoid System: A Target for Cancer Treatment
title_short The Endocannabinoid System: A Target for Cancer Treatment
title_full The Endocannabinoid System: A Target for Cancer Treatment
title_fullStr The Endocannabinoid System: A Target for Cancer Treatment
title_full_unstemmed The Endocannabinoid System: A Target for Cancer Treatment
title_sort endocannabinoid system: a target for cancer treatment
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2020-01-01
description In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
topic cannabinoids
metastasis
cancer stem cell
angiogenesis
url https://www.mdpi.com/1422-0067/21/3/747
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