Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA.

Like many other ancient genes, the cystic fibrosis transmembrane conductance regulator (CFTR) has survived for hundreds of millions of years. In this report, we consider whether such prodigious longevity of an individual gene--as opposed to an entire genome or species--should be considered surprisin...

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Bibliographic Details
Main Authors: Aubrey E Hill, Zackery E Plyler, Hemant Tiwari, Amit Patki, Joel P Tully, Christopher W McAtee, Leah A Moseley, Eric J Sorscher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4211684?pdf=render

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