The State and Interactions of the System of Cytokines in Autoimmune Thyrotoxicosis

• Format: Article
• Language: Russian
• Published: Endocrinology Research Centre 2013-12-01
• Series: Клиническая и экспериментальная тиреоидология
• Subjects: autoimmune thyrotoxicosis; cytokines; thiamazole
• Online Access: https://cet-endojournals.ru/ket/article/viewFile/6567/4344

One of the key, as well as regulatory, roles in immune response is given to the system of cytokines. The change in the content of serum opposite’s cytokines in GD is dynamic. The beginning of autoimmune thyrotoxicosis shows the largest amounts of cytokines - IL-1α and IL-1β, IFN-γ, IL-17, TGF-β and IL-10. It has been proved that there is a direct correlation dependence of the degree of the severity of the autoimmune thyrotoxicosis on the content of proinflammatory (IL-1α and IL-1β, IFN-γ, IL-17) and anti-inflammatory TGF-β, IL-10 cytokines in the patient’s blood serum, as well as on the production of anti-receptive thyroid autoantibodies. The benefits of study indexed that, long-term Thiamazole treatment in generally accepted standard doses demonstrates significant reduction of cytokine volume. It has also made it possible to work out the algorithm of the development of autoimmune thyrotoxicosis recurrence.